A new paper titled “Monolithic, 3D-printed lab-on-disc platform for multiplexed molecular detection of SARS-CoV-2” is published in the journal of “Sensors and Actuators B: Chemical”. The lab-on-a-disc system consists of a monolithic, 3D-printed microfluidic disc, a mini centrifuge, and a mini block heater, allowing on-site deployment for SARS-CoV-2 detection. The disc is one-step 3D-printed, avoiding the aligning and binding processes of multiple layers during the farbrication of conventional PMMA discs. In the disc, three SARS-CoV-2 genes and one inner control gene from human genome can be detected simultaneously within 50 min and the detection possesses high sensitivity (100 copies per disc) and high specificity (no cross-reactivity). Also, the system has been clinically validated by testing twenty swab samples. This lab-on-a-disc system is therefore simple, rapid, disposable, sensitivit, reliabe, and multiplexed to streamline COVID-19 diagnostics.
Reference: Xiong Ding, Ziyue Li, Changchun Liu. Monolithic, 3D-Printed Lab-on-Disc Platform for Multiplexed Molecular Detection of SARS-CoV-2. Sensors and Actuators B: Chemical. 2021, 351:130998. https://doi.org/10.1016/j.snb.2021.130998
Advanced Molecular Diagnostics & Devices Lab (AMDDL) 